Ginsenoside RG1‐induced mesenchymal stem cells alleviate diabetic cardiomyopathy through secreting exosomal circNOTCH1 to promote macrophage M2 polarization

• DOI: 10.1002/ptr.8018
• Publication Date: 2023-09-23T04:53:33Z
• Authors: Juan Zhen; Jinping Bai; Jia Liu; Hongbo Men; Haitao Yu
• Keywords: Diabetic Cardiomyopathy; Cardiac Fibrosis; Macrophage polarization; Myocardial fibrosis; Exosome

Abstract Diabetic cardiomyopathy (DCM) is a cardiac complication resulting from long‐term uncontrolled diabetes, characterized by myocardial fibrosis and abnormal function. This study aimed at investigating the potential of ginsenoside RG1 (RG1)‐induced mesenchymal stem cells (MSCs) in alleviating DCM. A DCM mouse model was constructed, effects RG1‐induced MSCs on function diabetic mice were evaluated. cocultured with high glucose‐treated fibroblasts for subsequent functional mechanism assays. It discovered that secrete exosomes induce macrophage M2 polarization. Mechanistically, derived transferred circNOTCH1 into macrophages, activating NOTCH signaling pathway. competing endogenous RNA (ceRNA) regulatory axis consisting circNOTCH1, miR‐495‐3p, NOTCH1 found to contribute alleviation.. unveiled exosomal secreted can alleviate pathway finding may development new therapeutic approaches