Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia‐induced pulmonary hypertension

• DOI: 10.1002/pul2.12015
• Publication Date: 2021-12-15T15:15:23Z
• Authors: Aline C. Oliveira; Tao Yang; Jing Li; Ravindra K. Sharma; Marianthi K. Karas; Andrew J. Bryant; Annette D. de Kloet; Eric G. Krause; Bina Joe; Elaine M. Richards; Mohan K. Raizada
• Keywords: Hypoxia; Pathophysiology; Dysbiosis; Angiotensin-converting enzyme 2

Recent evidence suggests pulmonary hypertension (PH), a disease of the vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted effects chronic hypoxia to prevent hypertension, neuroinflammation, gut dysbiosis in wild type recipients.