High incidence of decidualization failure in infertile women

• DOI: 10.1002/rmb2.12580
• Publication Date: 2024-05-16T09:42:35Z
• Authors: Isao Tamura; Yumiko Doi‐Tanaka; Akihisa Takasaki; Katsunori Shimamura; Toshihide Yoneda; Hitomi Takasaki; Amon Shiroshita; Taishi Fujimura; Yuichiro Shirafuta; Norihiro Sugino
• Keywords: Decidualization; Implantation failure; Decidual cells; Decidua

Abstract Purpose Decidualization is an important event for embryo implantation and successful pregnancy. Impaired decidualization leads to failure miscarriage. However, it unclear how often occurs in infertile women. By analyzing the endometrium at late‐secretory phase, we investigated incidence pathogenesis of among Methods Endometrial dating was performed on endometria obtained phase from 33 more than 2 days delay taken as indication failure. The expression essential transcription factors (FOXO1, WT1, C/EBPβ) examined by immunohistochemistry. Results Among 32 cases, 20 cases (62.5%) showed These patients tended have a history frequent miscarriages those without percentage cells that immunostained positive three significantly lower with Serum progesterone levels measured mid‐ were not different between Conclusions high