Efficient Copper‐Promoted Tandem Multi‐Component Strategy: The Synthesis of 1‐ Aryl/Alkyl‐5‐(N‐Benzoylamino) Tetrazoles and Guanidine's

• DOI: 10.1002/slct.201702568
• Publication Date: 2017-12-13T07:12:44Z
• Authors: Baji vali Shaik; Mohan Seelam; Ramana Tamminana; Prasad Rao Kammela
• Keywords: Guanidine; Tandem; Component (thermodynamics); Benzoyl chloride

Abstract Efficient, simple and multi component methodology has been demonstrated for the construction of l‐Aryl/Alkyl‐5‐( N ‐Benzoylamino) tetrazoles guanidine's. These compounds can be used as intermediates synthesis heterocyclic such substituted 2‐( N‐ benzoyl) benzimidazoles fused cyclic tetrazoles. Target products were obtained from benzyol chloride via in situ consecutive formation benzoyl isothiocyanates aryl thiourea. Moreover, desulphurization was also observed during this methodology. In addition, functional group tolerance reaction mechanism have studied.