Investigating the Efficacy of Silver Anethum graveolens Nano‐Extract in Colon Cancer Radiotherapy

• DOI: 10.1002/slct.202405345
• Publication Date: 2025-03-19T18:57:27Z
• Authors: Farshad Seyed Nejad; Mostafa Alizade‐H...; Mehdi Haghi; Rokhsareh Ebrahimi; Mohammad Mahdi Za...; Alireza Farajollahi; Roghayeh Fathi; Reza Mohammadi; Samira Samadi Mia...; Mohammad Heydarne...; Baharak Divband; Amin Ahmadi

AbstractMagnetic silver nanoparticles are intelligent magnetic particles that have high intelligence and a large absorption surface area. Their small size and wide absorption surface make them effective drug carriers to the cancer site. In this research, the properties of the green formulation of silver nanoparticles by Anethum graveolens on colon carcinoma cells were checked. The Ag‐bionanoparticles synthesized using green formulation underwent characterization through FT‐IR, XRD, EDS‐mapping, and SEM techniques. The aim of this work is to study the decrease in cell viability and BCL2 expression and the increase in BAX expression with silver nanoparticles (AgNPs) synthesized using Anethum graveolens extract, especially when combined with radiation therapy. By performing MTT assay, cell survival and by qPCR assay, expression of pro‐apoptotic BAX and anti‐apoptotic BCL2 were evaluated. With more clinical trials, these green synthesized nanoparticles can be used to treat colon cancer.