Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty

• DOI: 10.1002/smll.202203003
• Publication Date: 2022-06-19T19:25:07Z
• Authors: Xinyu Tan; Ethan Gerhard; Yuqi Wang; Richard T. Tran; Hui Xu; Su Yan; Elias B. Rizk; April D. Armstrong; Yuxiao Zhou; Jing Du; Xiaochun Bai; Jian Yang
• Keywords: Putty; Biomaterial

The burden of bone fractures demands development effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi-functional implants to avoid complications including osseous hemorrhage, infection, and nonunion. Bone wax has been widely used in orthopedic control due its simplicity use conformation irregular defects; however, nondegradability results impaired healing, risk significant inflammatory responses. Herein, a class intrinsically fluorescent, osteopromotive citrate-based polymer/hydroxyapatite (HA) composites (BPLP-Ser/HA) highly malleable press-fit putty is designed. BPLP-Ser/HA displays mechanics replicating early nonmineralized (initial moduli from ≈2-500 kPa), hydration induced mechanical strengthening physiological conditions, tunable degradation rates (over 2 months), low swelling ratios (<10%), clotting hemostatic sealing potential (resistant blood pressure >24 h) adhesion (≈350-550 kPa). Simultaneously, citrate's bioactive properties result antimicrobial (≈100% 55% inhibition S. aureus E. coli) effects. Finally, demonstrates vivo regeneration critical-sized rat calvaria model equivalent gold standard autograft. represents simple, off-the-shelf solution combined challenges wound management subsequent regeneration.