Vitality‐Enhanced Dual‐Modal Tracking System Reveals the Dynamic Fate of Mesenchymal Stem Cells for Stroke Therapy (Small 47/2022)

• DOI: 10.1002/smll.202270256
• Publication Date: 2022-11-25T03:10:36Z
• Authors: Jianpei Xu; Yuwen Zhang; Yipu Liu; Yang You; Fengan Li; Yu Chen; Laozhi Xie; Shiqiang Tong; Songlei Zhou; Kaifan Liang; Yukun Huang; Gan Jiang; Qingxiang Song; Ni Mei; Fenfen Ma; Xiaoling Gao; He Wang; Jun Chen
• Keywords: Penumbra; Vitality; Stroke; Tracking (education)

Stroke Therapy In article number 2203431, Xiaoling Gao, He Wang, Jun Chen, and co-workers engineer mesenchymal stem cells (MSCs) with near-infrared (NIR) magnetic resonance (MR) dual-modal tracking nanoparticles via a bioorthogonal method. An antioxidant layer covered on the MSCs' surface enhances their vitality in harsh stroke microenvironment. The vitality-enhanced MSCs remigrate from penumbra to infarct core act just like firemen struggling fire save lives.