Extracorporeal Blood Treatment Using Functional Magnetic Nanoclusters Mitigates Organ Dysfunction of Sepsis in Swine

• DOI: 10.1002/smtd.202301428
• Publication Date: 2024-01-01T04:50:56Z
• Authors: Sung Jin Park; Inwon Park; Suhyun Kim; Min Kyu Kim; Seonghye Kim; Hwain Jeong; Dongsung Kim; Seung Woo Cho; Tae‐Eun Park; Aleksey Ni; Hankwon Lim; Jinmyoung Joo; Jae Hyuk Lee; Joo H. Kang
• Keywords: Extracorporeal; Nanoclusters; Organ dysfunction

Abstract Mitigating sepsis‐induced severe organ dysfunction with magnetic nanoparticles has shown remarkable advances in extracorporeal blood treatment. Nevertheless, treating large septic animals remains challenging due to insufficient separation at rapid flow rates (>6 L h −1 ) and limited incubation time an circuit. Herein, superparamagnetic nanoclusters (SPNCs) coated red cell (RBC) membranes are developed, which promptly capture magnetically separate a wide range of pathogens high swine sepsis model. The SPNCs exhibited ultranarrow size distribution clustered iron oxide nanocrystals exceptionally saturation magnetization (≈ 90 emu g close that bulk magnetite. It is also revealed CD47 on the RBCs allows RBC‐SPNCs remain consistent concentration by evading innate immunity. uniform greatly enhances their effectiveness eradicating various pathogenic materials blood. use for treatment infected multidrug‐resistant E. coli validated found bacteremic significantly mitigated after 12 h. findings highlight potential application therapy animal models potentially humans.