Safe Induction of Acute Inflammation with Enhanced Antitumor Immunity by Hydrogel‐Mediated Outer Membrane Vesicle Delivery

• DOI: 10.1002/smtd.202301620
• Publication Date: 2024-02-12T07:04:24Z
• Authors: Wenjie Xu; Xinyan Hao; Yongjiang Li; Yucheng Tang; Xiaohan Qiu; Min Zhou; Jihua Liu; Si Huang; Dehua Liao; Xiongbin Hu; Tiantian Tang; Junyong Wu; Daxiong Xiang
• Keywords: Inflammation; 0301 basic medicine; Neutrophils; Photothermal Therapy; Hydrogels; Mice; 03 medical and health sciences; Bacterial Outer Membrane; Cell Line, Tumor; Animals; Humans; Female; Immunotherapy

Abstract Acute inflammation has the potential for recruitment of immune cells, inhibiting tumor angiogenesis, metastasis, and drug resistance thereby overcoming immunosuppressive microenvironment caused by chronic inflammation. Here, an acute inducer using bacteria outer membrane vesicles (OMVs) loaded in thermal‐sensitive hydrogel (named OMVs‐gel) localized controlled release OMVs sites is proposed. trigger neutrophil amplify inside tissues. The ensures drastic confined within tumor, addressing biosafety concerns that direct administration free may cause fatal effects. This strategy eradicated solid tumors safely rapidly. study further elucidates one possible mechanisms OMVs‐gel therapy, which involves assembly antitumor neutrophils elastase selective killing. Additionally, vascular destruction induced results darkening, allowing combinational photothermal therapy. findings suggest use can induce enhance immunity, representing a promising to promote application immunotherapy.