Chitosan‐Stabilized PtAu Nanoparticles with Multienzyme‐Like Activity for Mixed Bacteria Infection Wound Healing and Insights into Its Antibacterial Mechanism

• DOI: 10.1002/sstr.202300553
• Publication Date: 2024-03-26T04:20:46Z
• Authors: Yujuan Wen; Wenxin Chen; Ruimei Wu; Jianpeng Guo; Xin Liu; Boling Shi; Cunshan Zhang; Lina Wu; Yanjie Zheng; Ailin Liu; Liqing Lin
• Keywords: antibacterial; Chemistry; transcriptome analysis; Physics; QC1-999; wound healing; nanozymes; QD1-999; 01 natural sciences; 0104 chemical sciences

Traditional antibacterial agents are often observed to be ineffective because bacteria evolved strains with greater antibiotic resistance. Here, vigorous chitosan‐stabilized PtAu nanoparticles (CSPA) multienzyme‐like activity successfully fabricated, which serve an effective artificial nanozyme enhance for mixed bacterial infection wound treatment. Ultrasmall size CSPA exhibits excellent hydrophilicity and biocompatibility, possesses strong oxidase‐ peroxidase‐like generating a substantial amount of ROS (, 1 O 2 , ·OH) cause oxidative damage bacteria, also demonstrates nicotinamide adenine dinucleotide dehydrogenase‐like disrupting the respiratory chains, subsequently impedes adenosine triphosphate production. favorable broad‐spectrum at very low concentrations, prevents resistance, completely inhibits biofilm formation. Antibacterial Mechanism by transcriptomics is further revealed that can induce stress, hinder energy metabolism, disrupt synthesis function cell walls membranes. In vivo, population site promotes healing in rats. This study introduces novel approach, providing important insight into mechanism nanozymes promoting advancement nanocatalytic materials biomedical applications.