Suppression of Neutrophil-Mediated Tissue Damage—A Novel Skill of Mesenchymal Stem Cells

• DOI: 10.1002/stem.2417
• Publication Date: 2016-06-14T16:05:03Z
• Authors: Dongsheng Jiang; Jana Muschhammer; Yu Qi; Andrea Kügler; Juliane C. de Vries; Mona Saffarzadeh; Anca Sindrilaru; Seppe Vander Beken; Meinhard Wlaschek; Mark A. Kluth; Christoph Ganss; Natasha Y. Frank; Markus H. Frank; Klaus T. Preissner; Karin Scharffette...
• Keywords: Neutrophil Extracellular Traps; Neutrophil elastase

Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration. Though of prime interest, their potentially protective role on neutrophil-induced damage, associated with high morbidity mortality, has not been explored in sufficient detail. Here we report the therapeutic skill MSCs to suppress unrestrained neutrophil activation attenuate severe damage a murine immune-complex mediated vasculitis model unbalanced activation. MSC-mediated suppression was due intercellular adhesion molecule 1-dependent engulfment neutrophils by MSCs, decreasing overall numbers. Similar endogenous niche human vasculitis, therapeutically injected via upregulation extracellular superoxide dismutase (SOD3), reduced anion concentrations consequently prevented death, trap formation spillage matrix degrading elastase, gelatinase myeloperoxidase. SOD3-silenced did exert effects. Thus, hold substantial promise counteract conditions Stem Cells 2016;34:2393-2406.