Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat

• DOI: 10.1002/tox.22242
• Publication Date: 2016-02-16T08:57:00Z
• Authors: Yoon Cho; Jung‐hee Lim; Mi‐Kyung Song; Seung‐Chan Jeong; Kyuhong Lee; Yongju Heo; Tae Sung Kim; Jae‐Chun Ryu
• Keywords: Toxicogenomics; Inhalation exposure

Hexanal is a major component of indoor air pollutants and kind aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study transcriptomic analysis to determine the mode toxic actions response hexanal. Fischer 344 rats both sexes were exposed by hexanal aerosol for 4 h day-1 , 5 days week-1 weeks at 0, 600, 1000, 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes three doses hexanal; among these genes, 11 showed dose-dependent patterns (10 downregulated 1 upregulated, 1.5-fold, p < 0.05). Through comparative toxicogenomics database (CTD) determined that five (CCL12, DDIT4, KLF2, CEBPD, ADH6) are linked diverse disease categories such as cancer, respiratory tract disease, immune system disease. These diseases previously known being induced volatile organic compounds (VOCs). Our data demonstrated hexanal-induced altered could be valuable quantitative biomarkers predict exposure perform relative risk assessments, including pulmonary toxicity. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 382-396, 2017.