Repeated exposure to iron oxide nanoparticles causes testicular toxicity in mice

• DOI: 10.1002/tox.22262
• Publication Date: 2016-03-19T07:09:25Z
• Authors: Kiruthika Sundarraj; Vijayprakash Mani...; Azhwar Raghunath; Madhivadhani Peri...; Mangala Priya Vis...; Ekambaram Perumal
• Keywords: Vacuolization; Reproductive toxicity; Malondialdehyde

ABSTRACT The aim of this study was to determine whether repeated exposure iron oxide nanoparticles (Fe 2 O 3 ‐NPs) could be toxic mice testis. Fe ‐NPs (25 and 50 mg/kg) were intraperitoneally administered into once a week for 4 weeks. Our showed that have the ability cross blood‐testis barrier get findings resulted in accumulation which evidenced from content Furthermore, 25 mg/kg administration increased reactive oxygen species, lipid peroxidation, protein carbonyl content, glutathione peroxidase activity, nitric levels with concomitant decrease antioxidants—superoxide dismutase, catalase, glutathione, vitamin C. Increased expression Bax, cleaved‐caspase‐3, cleaved‐PARP confirms apoptosis. Serum testosterone concentration exposure. In addition, histopathological lesions like vacuolization, detachment, sloughing germ cells also observed response treatment. data our entailed testicular toxicity caused by may associated leading oxidative stress Therefore, precautions should taken safe use avoid complications fertility males. Further research will unravel possible molecular mechanisms on ‐NPs. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 594–608, 2017.