8:2 Fluorotelomer alcohol causes immunotoxicity and liver injury in adult male C57BL/6 mice

• DOI: 10.1002/tox.22668
• Publication Date: 2018-12-08T06:44:49Z
• Authors: Xia Wang; Baida Kong; Bingnan He; Lai Wei; Jianbo Zhu; Yuanxiang Jin; Yudong Shan; Weitao Wang; Chunqiang Pan; Zhengwei Fu
• Keywords: Splenocyte

Abstract 8:2 Fluorotelomer alcohol (8:2 FTOH) is widely used in houseware and industrial goods ubiquitous the surrounding environment. FTOH has been linked to hepatoxicity, nephrotoxicity, reproductive toxicity, as well endocrine‐disrupting effects. However, of yet, research regarding immunotoxicity remains largely limited. In present study, adult male C57BL/6 mice were administered with 10, 30, 100 mg/kg/d by gavage for 28 days investigate its vivo. The results showed that exposure caused increases liver weight histological changes liver, including vacuolation, cell swelling, immune infiltration, karyopyknosis nuclear swelling. No change either spleen or thymus was observed after administration FTOH. addition, reduced concentration IL‐1β serum, mRNA levels IL‐1β, IL‐6 , TNF‐α both spleen. CXCL‐1 expression downregulated administration, while only upregulated liver. Moreover, primary cultured splenocytes inhibited ConA‐stimulated proliferation at concentrations 30 μM, LPS‐stimulated μM. Furthermore, level secreted IFN‐γ splenocytes. obtained study demonstrated posed potential injury mice. Our findings will provide novel data health risk assessment