Association of clinical characteristics and lifestyle factors with fecal S100/calgranulin concentrations in healthy dogs

• DOI: 10.1002/vms3.469
• Publication Date: 2021-03-10T12:09:01Z
• Authors: Romy M. Heilmann; Melissa M. Guard; Linda Toresson; Stefan Unterer; Aurélien Grellet; Niels Grützner; Jan S. Suchodolski; Joerg M. Steiner
• Keywords: obesity; [SDV]Life Sciences [q-bio]; Veterinary medicine; 610; canine; reproductive status; calprotectin; 630; 0403 veterinary science; Veterinary science; Feces; Dogs; SF600-1100; Animals; Life Style; 2. Zero hunger; S100A12 Protein; Original Articles; 04 agricultural and veterinary sciences; vaccination; inflammatory marker; 3. Good health; S100A12; Female; Leukocyte L1 Antigen Complex

Fecal S100/calgranulin (S100A12 and calprotectin) concentrations are useful markers of gastrointestinal inflammation in dogs. In people, fecal affected by age, obesity, diet other lifestyle factors. Knowledge about the effects such factors on dogs is currently scarce.To evaluate association between several a large cohort healthy adult dogs.Single-spot samples from 181 pet data derived standard questionnaire served to effect sex, reproductive status, body weight condition, breed type size, vaccination, endoparasite treatment, diet, environment travel history calgranulin ratio (fCalR).Univariate analysis showed significant status (in female dogs) size with S100A12, calprotectin fCalR. Breed was linked S100A12 fCalR; recent vaccination (particularly vaccine against canine parvovirus) multivariate models, concentrations, concentrations.Breed can affect these biomarkers should be interpreted light those confounding The utility reference intervals for might improved through stratification sex/reproductive size. not confounded deworming, or history.