Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells

• DOI: 10.1007/978-3-030-65768-0_14
• Publication Date: 2021-05-20T11:20:30Z
• Authors: Christos Sazeides; Anne Le
• Keywords: Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that TME not only provides physical support for cells but also directs cell-to-cell interactions (in this case, interaction between CAFs). As progresses, CAFs coevolve, transitioning from inactivated state to activated state. The elucidation understanding will pave way new therapies [1-3].