Impact of MCT1 Haploinsufficiency on the Mouse Retina

• DOI: 10.1007/978-3-319-75402-4_46
• Publication Date: 2018-05-02T13:23:42Z
• Authors: Neal S. Peachey; Minzhong Yu; John Y. S. Han; Sylvain Lengacher; Pierre J. Magistr...; Luc Pellerin; Nancy J. Philp
• Keywords: Haploinsufficiency

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/- heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/- retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.