Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia

• DOI: 10.1007/bf00254604
• Publication Date: 2004-09-26T17:44:09Z
• Authors: HarveyD. Preisler; Teresa Gessner; Nozar Azarnia; Wanda Bolanowska; Joshua Epstein; AmyP. Early; Peter D'Arrigo; Ralph Vogler; Lee Winton; Paul Chervenik; Robert Joyce; Howard Lee; Robert Steele; Jack Goldberg; Arlan Gottlieb; George Browman; Kenneth Miller; Hans Grunwald; Richard Larson; James Brennan
• Keywords: Adult; Leukemia; Adolescent; Dose-Response Relationship, Drug; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Doxorubicin; Acute Disease; Humans; Aged

Plasma adriamycin and adriamycinol levels were measured in 45 patients with acute nonlymphocytic leukemia 3 h after the drug was administered. A wide range of levels as found. Plasma levels increased after the administration of each of the three daily doses of the drug. High plasma levels were associated with both death during remission induction therapy and, for patients who entered remission, long remissions.