Morphometric and histological examinations of dog kidneys after embolization of the renal artery with the cyanoacrylic glue “Chirurcol-Polfa”

• DOI: 10.1007/bf02083498
• Publication Date: 2005-08-14T19:11:43Z
• Authors: B. Cylwik; J. Darewicz; B. Karasewicz
• Keywords: 03 medical and health sciences; Dogs; Renal Artery; 0302 clinical medicine; Infarction; Animals; Atrophy; Enbucrilate; Kidney; Embolization, Therapeutic; 3. Good health

The renal artery in 20 mongrel dogs was embolized with cyanoacrylic glue "Chirurcoll-Polfa", introduced through a catheter. The extent of the resulting renal infarction of the kidneys was evaluated morphometrically and was found to be 71.35 to 91.43% of the volume of the embolized kidneys (mean 77.61%). Histological examinations revealed no resorption of the glue after 3 months. In the embolized vessels, after 7 days tumefaction and degeneration of the reticulin, elastic, and collagen fibres were observed, after 24 days inflammatory changes, and after 2 and 3 months respectively, secondary collagenization and hyalinization. Inflammatory changes were also found in the perivascular tissue. In the sections of the kidneys not involved in the infarction a progressive atrophy of the nephrons and fibrosis of the parenchyma were observed 2 and 3 months after embolization.