Apoptosis and aging in mitochondrial morphology mutants ofS. cerevisiae

• DOI: 10.1007/bf02932107
• Publication Date: 2008-08-09T10:00:14Z
• Authors: V. Palermo; C. Falcone; C. Mazzoni
• Keywords: Adenosine Triphosphatases; 0303 health sciences; Saccharomyces cerevisiae Proteins; F-Box Proteins; Apoptosis; Saccharomyces cerevisiae; GTP Phosphohydrolases; Mitochondria; Mitochondrial Proteins; F Factor; Oxidative Stress; 03 medical and health sciences; ATP-Dependent Proteases; Mutation

Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.