The Multidrug Transporters Belonging to Major Facilitator Superfamily (MFS) in Mycobacterium tuberculosis

• DOI: 10.1007/bf03402035
• Publication Date: 2018-09-06T08:45:54Z
• Authors: Edda De Rossi; Patrizio Arrigo; Marco Bellinzoni; Pedro E. A. Silva; Carlos Martin; José A. Aínsa; Paola Guglierame; Giovanna Riccardi
• Keywords: Major facilitator superfamily; Efflux; Subfamily

Both intrinsic and acquired multidrug resistance play an important role in the insurgence of tuberculosis. Detailed knowledge molecular basis drug recognition transport by systems is required for development new antibiotics that are not extruded or inhibitors block transporter allow traditional to be effective. We have undertaken inventory transporters subfamily, included major facilitator superfamily (MFS), encoded complete genome Mycobacterium tuberculosis (MTB). These proteins were identified on their characteristic stretches amino acids transmembrane segments (TMS) number. Genome analysis searches homology between characterized other organisms revealed 16 open reading frames encoding putative efflux pumps belonging MFS. In case two them, we also demonstrated they function as proteins.