Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3

• DOI: 10.1007/s00018-020-03640-6
• Publication Date: 2020-09-21T17:32:19Z
• Authors: Grzegorz Wiera; Katarzyna Lebida; Anna Maria Lech; Patrycja Brzdąk; Inge Van Hove; Lies De Groef; Lieve Moons; Enrica Maria Petrini; Andrea Barberis; Jerzy W. Mozrzymas
• Keywords: Gephyrin

Abstract Learning and memory are known to depend on synaptic plasticity. Whereas the involvement of plastic changes at excitatory synapses is well established, plasticity mechanisms inhibitory only start be discovered. Extracellular proteolysis a key factor in glutamatergic but nothing about its role GABAergic synapses. We reveal that pharmacological inhibition MMP3 activity or genetic knockout Mmp3 gene abolishes induction postsynaptic iLTP. Moreover, application exogenous active mimics major iLTP manifestations: increased mIPSCs amplitude, enlargement gephyrin clusters, decrease diffusion coefficient GABA A receptors favors their entrapment within synapse. Finally, we found deficient mice show faster spatial learning Morris water maze enhanced contextual fear conditioning. conclude plays behaviors presumably part