Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression

• DOI: 10.1007/s00018-023-05030-0
• Publication Date: 2023-11-25T03:01:32Z
• Authors: Chong Li; Ling Zhu; Jun-Xia Liu; Jing Guo; Juan Xie; Chun-Meng Shi; Qing-Yuan Sun; Guo-Ning Huang; Jing-Yu Li
• Keywords: Cordycepin

Abstract Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing success rate assisted reproductive technology (ART). Potential preventative strategies preventing oocytes from associated underlying mechanisms warrant investigation. In this study, we identified that cordycepin, a natural nucleoside analogue, promoted vitro, as indicated by reduced fragmentation, improved spindle/chromosomes morphology mitochondrial function, well increased developmental competence. Proteomic RNA sequencing analyses revealed cordycepin inhibited degradation several crucial maternal proteins mRNAs caused aging. Strikingly, was found suppress elevation DCP1A protein inhibiting polyadenylation during postovulatory aging, consequently impeding decapping mRNAs. humans, total mRNA also cordycepin. Collectively, our findings demonstrate prevents mammalian inhibition via suppressing mRNA, promoting