MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury

• DOI: 10.1007/s00018-023-05096-w
• Publication Date: 2024-01-30T10:02:41Z
• Authors: Haiyan Jiang; Boya Liu; Junfei Lin; Tong Xue; Yimin Han; Chunfeng Lu; Songlin Zhou; Yun Gu; Feng Xu; Yuntian Shen; Lingchi Xu; Hualin Sun
• Keywords: Homeostasis

Abstract Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to external stimuli injuries, range stem/progenitor cells, with stem cells or satellite (MuSCs) being the predominant cell type, are rapidly activated repair regenerate skeletal within weeks. Under normal conditions, MuSCs remain quiescent state, but become proliferative differentiate into new injury. addition MuSCs, some interstitial progenitor (IPCs) such as fibro-adipogenic progenitors (FAPs), pericytes, expressing PW1 negative for Pax7 (PICs), side population (SPCs), CD133-positive Twist2-positive have been identified playing direct indirect roles regenerating tissue. Here, we highlight heterogeneity, molecular markers, functional properties these explore role homeostasis, aging, muscle-related diseases. This review provides critical insights future therapies aimed at treating