AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling

• DOI: 10.1007/s00018-024-05326-9
• Publication Date: 2024-06-25T18:08:15Z
• Authors: Qian Jiang; Yayun Chen; Siping Zheng; Lina Sui; Dalang Yu; Furong Qing; Wenji He; Qiuxiang Xiao; Tianfu Guo; Li Xu; Zhichun Liu; Zhiping Liu
• Keywords: AIM2; Pyroptosis

Candida albicans is among the most prevalent invasive fungal pathogens for immunocompromised individuals and novel therapeutic approaches that involve immune response modulation are imperative. Absent in melanoma 2 (AIM2), a pattern recognition receptor DNA sensing, well recognized its involvement inflammasome formation crucial role safeguarding host against various pathogenic infections. However, of AIM2 defense C. infection remains uncertain. This study reveals gene expression induced human mouse innate cells or tissues after infection. Furthermore, compared to their wild-type (WT) counterparts, Aim2