Neutrophil-modulated Dicer expression in macrophages influences inflammation resolution

• DOI: 10.1007/s00018-025-05644-6
• Publication Date: 2025-03-13T02:47:52Z
• Authors: Zhishang Wang; Wenhua Li; Jia Li; Tianrong Jin; Hong Chen; Feihong Liang; Shengran Liu; Jialin Jia; Tingting Liu; Yu Liu; Liming Yu; Xiaodong Xue; Jikai Zhao; Tao Huang; Xinyi Huang; Huishan Wang; Yongsheng Li; Bangwei Luo; Zhiren Zhang
• Keywords: Dicer

The precise molecular mechanisms through which neutrophils regulate macrophages in the progression and resolution of acute inflammation remain poorly understood. Here, we present new findings on role Dicer regulating macrophage phenotypic transitions essential for proper inflammatory resolution, influenced by neutrophils. Using a zymosan A (Zym A)-induced self-limited mouse peritonitis model, observed that expression was significantly reduced neutrophil-derived IFN-γ during phase, but gradually returned to normal levels phase following engulfment apoptotic Our study macrophage-specific Dicer1-depletion (Dicer1-CKO) mice demonstrated these more severe characterized increased pro-inflammatory cytokines enhanced neutrophil trafficking. Additionally, impaired Dicer1-CKO mice, leading accumulation uncleared Specifically, absence resulted M1 polarization heightened bactericidal activity, facilitating inflammation. Conversely, inducing promoted transition M2 polarization, enhancing cell clearance expediting suggest plays central inflammation, with implications treatment diseases.