3,4-Dihydropyrimidin-2(1H)-one derivatives: Organocatalysed microwave assisted synthesis and evaluation of their antioxidant activity

• DOI: 10.1007/s00044-012-9987-z
• Publication Date: 2012-02-22T08:17:27Z
• Authors: Nidhi Gangwar; Virendra Kumar Ka...
• Keywords: Oxalic Acid; Biginelli reaction

3,4-Dihydropyrimidin-2(1H)-one derivatives were synthesized by Biginelli reaction under microwave irradiation using oxalic acid as a new, efficient, and environmentally benign catalyst. Antioxidant properties of synthesized compounds were evaluated by three methods, viz., radical scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals, reducing power and Fe2+ chelating activities. The compounds having –OH group on benzene ring were found to have higher activity. Amongst the 12 synthesized compounds, four were found to have significant antioxidant activity.