Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

• DOI: 10.1007/s00044-014-1006-0
• Publication Date: 2014-04-25T09:33:11Z
• Authors: Ravindra M. Kumbhare; Tulshiram L. Dadmal; R. Pamanji; Umesh B. Kosurkar; L. R. Velatooru; K. Appalanaidu; Y. Khageswara Rao; J. Venkateswara Rao
• Keywords: Benzothiazole; Cancer cell lines; 1,2,4-Triazole; Triazole

A new series of fluoro 1,2,3-triazole tagged amino bis (benzothiazole) derivatives 8, 9 were prepared starting from 2-amino benzothiazole in four steps via amination, cyclization, alkylation followed by reaction with various azides under sharpless conditions through click chemistry approach. All newly synthesized compounds were screened for their antimicrobial and cytotoxic activity against four human cancer cell lines (U937, THP-1, Colo205, and A549), and promising compounds have been identified.