Phytochemical characterization and biological activity of secondary metabolites from three Limonium species

• DOI: 10.1007/s00044-017-1973-z
• Publication Date: 2017-07-12T00:59:54Z
• Authors: Anastassiya V. Ga...; Shaymaa M. Mohamed; Amer H. Tarawneh; Nesma M. Mohamed; Guoyi Ma; Boris N. Ponomarev; Galiya E. Zhusupova; Charles L. Cantrell; Stephen J. Cutler; Samir A. Ross
• Keywords: Phytochemical

The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2–21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1–21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14 showed a significant activity against Trypanosoma brucei.