Prognostic factors in patients with T1 glottic cancer treated with radiotherapy

• DOI: 10.1007/s00066-019-01481-2
• Publication Date: 2019-06-18T11:02:32Z
• Authors: A. Mucha-Małecka; A. Chrostowska; K. Urbanek; K. Małecki
• Keywords: Male; 2. Zero hunger; Glottis; Middle Aged; Prognosis; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Carcinoma, Squamous Cell; Humans; Original Article; Female; Dose Fractionation, Radiation; Poland; Neoplasm Grading; Laryngeal Neoplasms; Aged; Neoplasm Staging; Retrospective Studies

Presentation of long-term results radiation treatment in patients with T1 glottic cancer and evaluation prognostic factors. We performed a retrospective analysis group 569 squamous cell carcinoma treated radiotherapy at the Center Oncology Cracow between 1977 2007. In all, 503 (88%) presented T1a stage disease 66 (12%) T1b. Anterior commissure infiltration was present 179 (31%) patients. Average hemoglobin level prior to therapy 13.9 g/dl. Using body mass index (BMI), 114 (20%) were underweight, 91 (16%) overweight. Median time collecting tumor specimen beginning 56 days (range 14–145 days). Treatment regimen normofractionated single fraction ≤2 Gy 102 (18%) hypofractionated 467 (82%) The 5‑ 10-year overall survival (OS), disease-specific (DSS) local control (LC) rates 85 68%, 88 86%, 89 87%, respectively. Multivariate showed that tobacco smoking, low (<13 g/dl), anterior infiltration, dose from longer than 30 had negative impact on LC DSS. Patients' age over 60 years, worse performance status malnutrition (BMI <18.5) impacts OS. Radiotherapy is highly effective method T1N0M0 cancer. DSS may be improved following hypofractionation, smoking cessation, shortening waiting-time until start treatment. OS mainly influenced by nutritional status.