Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases—an Augsburg University Medical Center experience

• DOI: 10.1007/s00066-021-01831-z
• Publication Date: 2021-08-20T15:07:42Z
• Authors: Klaus-Henning Kahl; Nikolaos Balagiannis; Michael Höck; Sabine Schill; Zoha Roushan; Ehab Shiban; Heiko Müller; Ute Grossert; Ina Konietzko; Björn Sommer; Christoph J. Maurer; Ansgar Berlis; Volkmar Heidecke; Tilman Janzen; Georg Stüben
• Keywords: ddc:610; Academic Medical Centers; Brain Neoplasms; X-Rays; 3. Good health; Radiography; 03 medical and health sciences; 0302 clinical medicine; Local control ; Academic Medical Centers [MeSH] ; Brain Neoplasms/radiotherapy [MeSH] ; Cavity boost ; Radiography [MeSH] ; Humans [MeSH] ; Brain Neoplasms/surgery [MeSH] ; Retrospective Studies [MeSH] ; X-Rays [MeSH] ; Postoperative ; Original Article ; IORT ; Neoplasm Recurrence, Local/radiotherapy [MeSH] ; Radionecrosis ; Brain Neoplasms/diagnostic imaging [MeSH]; Humans; Original Article; Neoplasm Recurrence, Local; Retrospective Studies

Abstract Purpose External-beam radiotherapy (EBRT) is the predominant method for localized brain radiotherapy (LBRT) after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50-kV x‑rays is an alternative way to focally irradiate the resection cavity after BM surgery, with the option of shortening the overall treatment time and limiting normal tissue irradiation.

Methods We retrospectively analyzed the outcomes of all patients who underwent neurosurgical resection of BM and 50-kV x‑ray IORT between 2013 and 2020 at Augsburg University Medical Center.

Results We identified 40 patients with 44 resected BM treated with 50-kV x‑ray IORT. Median diameter of the resected metastases was 2.8 cm (range 1.5–5.9 cm). Median applied dose was 20 Gy. All patients received standardized follow-up (FU) including 3‑monthly MRI of the brain. Mean FU was 14.4 months, with a median MRI FU for alive patients of 12.2 months. Median overall survival (OS) of all treated patients was 26.4 months (estimated 1‑year OS 61.6%). The observed local control (LC) rate of the resection cavity was 88.6% (estimated 1‑year LC 84.3%). Distant brain control (DC) was 47.5% (estimated 1‑year DC 33.5%). Only 25% of all patients needed WBI in the further course of disease. The observed radionecrosis rate was 2.5%.

Conclusion IORT with 50-kV x‑rays is a safe and appealing way to apply LBRT after neurosurgical resection of BM, with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early.