Dynamic pathophysiological features of early primary blast lung injury: a novel functional incapacity pig model

• DOI: 10.1007/s00068-024-02672-y
• Publication Date: 2025-01-24T16:10:41Z
• Authors: Shifeng Shao; Shasha Wu; Jun Liu; Zhikang Liao; Pengfei Wu; Yuan Yao; Zhen Wang; Liang Zhang; Yaoli Wang; Hui Zhao
• Keywords: Pathophysiology; Blast injury; Sports medicine

While there is evidence supporting the use of ultrasound for real-time monitoring primary blast lung injury (PBLI), uncertainties remain regarding timely detection early PBLI and limited data correlating it with commonly used clinical parameters. Our objective to develop a functional incapacity model that better addresses practical needs verify diagnostic effectiveness in identifying PBLI. We selected six healthy male pigs an animal using bio-shock tube (BST-I). The injuries were induced at pressure 4.8 MPa. monitored animals before after various methods detect changes vital signs, function, hemodynamics. experimental peak overpressure was measured 405.89 ± 4.14KPa, duration first positive being 50.01ms. mortality rate hours 50%. average Military Combat Injury Scale higher than 3. Significant increases observed heart (HR), shock index (SI), alveolar-arterial oxygen gradient (AaDO2), scores(LUS), pulmonary vascular permeability (PVPI) 0.5 h, 3 6 h after-injury (p < 0.05). Conversely, notable decreases arterial pressure(MAP), oxygenation (OI), stroke volume per heartbeat(SV), cardiac output power index(CPI), global end-diastolic (GEDI), intrathoracic blood (ITBI) during same time periods Meanwhile, extrapulmonary water (ELWI) showed significant increase At injury, scores positively correlated HR (R = 0.731, p 0.001), AaDO2 0.612, 0.012), SI 0.661, 0.004), ELWI 0.811, PVPI 0.705, 0.002). In contrast, these negatively SpO2 -0.583, 0.007),OI -0.772, ITBI -0.637, 0.006). have successfully developed novel, highly reproducible assessing serious incapacity. This displays immediate symptoms hypoxia, decreased output, volume, abnormal findings within syptoms lasting up h. Lung evaluation crucial assessment injuries, comparable