Antibiotika-Verbrauchs-Surveillance nach § 23 Infektionsschutzgesetz – Daten und Erfahrungen aus den Krankenhäusern in Frankfurt am Main, 2012–2017

• DOI: 10.1007/s00103-019-02993-z
• Publication Date: 2019-08-20T10:03:13Z
• Authors: Ursel Heudorf; Angelika Hausemann; Katrin Steul
• Keywords: 0301 basic medicine; Bacterial Infections; Drug Prescriptions; Drug Utilization; Hospitals; Anti-Bacterial Agents; 03 medical and health sciences; Drug Utilization Review; Germany; Health Care Surveys; Population Surveillance; Government Regulation; Humans

Since 2011, German hospitals have been requested to record and evaluate antibiotic use in their institution. In this publication, the use of antibiotics in hospitals belonging to the administrative district Frankfurt/Main between 2012 and 2017 is presented and discussed with regards to the targets set in 2014. These targets are to improve the perioperative prophylaxis, reduce the use of cefuroxime, and increase the penicillin/cephalosporin ratio.Since 2012, hospitals in Frankfurt/Main have been transmitting the defined daily doses (DDD) of all antibiotics used, the absolute number of patients, and their days of treatment. Since 2013, the data have also distinguished between intensive care and other units. The Frankfurt health authority calculated the total number of antibiotics and the DDD/100 patient days for all hospitals combined as well as for every hospital compared to each other.From 2012 to 2017, the number of absolute annual patient days increased from 1,592,161 to 1,615,180. Antibiotic use decreased from 1,073,975 DDD to 953,349 DDD, leading to a decrease from 67.5 DDD per 100 patient days to 59.0 DDD per 100 patient days. Cefuroxime was the most frequently used antibiotic in all hospitals. The use of cefuroxime showed a significant decrease between 2012 and 2017 (from 250,398 in 2012 to 165,160 DDD in 2017, a decrease of 34%). The use of ceftriaxone was reduced by 27%, ciprofloxacin by 9%, and levofloxacin by 16%.The targets set in 2014 were reached in the entirety of Frankfurt hospitals. However, there were significant differences between the hospitals taking part. The results were given as feedback to the hospitals in order to support their efforts in further improving antibiotic stewardship.