59-jähriger Patient mit rezidivierendem Erröten bei blander Leberzyste

• DOI: 10.1007/s00108-013-3433-2
• Publication Date: 2014-01-21T08:52:04Z
• Authors: S. Krug; A. König; D. Librizzi; W. Nimphius; T.M. Gress; P. Michl; A. Rinke
• Keywords: Diagnosis, Differential; Male; 03 medical and health sciences; 0302 clinical medicine; Cysts; Liver Neoplasms; Flushing; Humans; Middle Aged; Malignant Carcinoid Syndrome

A 59-year-old patient was admitted to hospital with recurrent flush symptoms and pathologically elevated 5-hydroxyindoleacetic acid (5-HIAA) levels in urine. A known cystic lesion of the liver which had been followed for years by ultrasound examinations and was regarded as a bland hepatic cyst was identified as a metastasis of a neuroendocrine neoplasm of the ileum. In two sequential surgical interventions the primary tumor with mesenteric lymph node metastases as well as the cystic liver metastasis could be resected. After surgical treatment an R1 situation at the mesenteric site and suspicious para-aortic lymph nodes remained. The long established treatment of factor-V Leiden mutation by anticoagulation with phenprocoumon was supplemented by deep subcutaneous injection of lanreotide autogel every 4 weeks. Currently, there is no evidence for progressive disease and the patient is without clinical signs of a carcinoid syndrome.