Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study

• DOI: 10.1007/s00125-006-0324-2
• Publication Date: 2006-06-20T05:54:41Z
• Authors: A. W. K. Tso; P. C. Sham; N. M. S. Wat; A. Xu; B. M. Y. Cheung; R. Rong; C. H. Y. Fong; J. Y. Xu; K. K. Y. Cheng; E. D. Janus; K. S. L. Lam
• Keywords: Adult; Blood Glucose; Male; China; Adiponectin - genetics; Pilot Projects; Gene; Polymerase Chain Reaction; Linkage Disequilibrium; Body Mass Index; 03 medical and health sciences; Genetic; 616; Glucose Intolerance; Hyperglycaemia; Humans; Glucose Intolerance - blood - genetics; Polymorphism; Promoter Regions, Genetic; Single-nucleotide polymorphism; 0303 health sciences; Polymorphism, Genetic; Diabetes; Impaired glucose tolerance; IGT; Middle Aged; 3. Good health; Female; Adiponectin; Follow-Up Studies

Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not Pima Indians. The aim this study was to determine contribution made by ADIPOQ variants glycaemic status southern Chinese individuals.Sixty unrelated subjects were screened for single-nucleotide polymorphisms (SNPs) direct sequencing. association tagging SNPs outcome 262 impaired glucose tolerance (IGT) examined a 5-year prospective study.We identified 15 gene, ten them constituting SNPs. At 5 years, 39.7% IGT had regressed NGT, 41.2% persistent or fasting 19.1% developed diabetes. Only T45G polymorphism hyperglycaemia at years (p=0.001). Haplotypes formed addition other SNPs, as haplotype blocks pairs, did confer greater than alone. On logistic regression analysis, independently predicted (OR=2.25, 95% CI 1.29-3.95, G carriers vs TT; p=0.005). It also nested case-control involving 158 sex- age-matched controls NGT (p=0.012, adjusted BMI), that glycaemia progression (p<0.05) meta-analysis included two published studies subjects.Our findings support significant role common predicting people.