Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice

• DOI: 10.1007/s00125-015-3523-x
• Publication Date: 2015-02-17T10:20:52Z
• Authors: Carmel M. McVicar; Micheal Ward; Liza M. Colhoun; Jasenka Guduric-F...; Angelika Bierhaus; Thomas Fleming; Andreas Schlotterer; Matthias Kolibabka; Hans-Peter Hammes; Mei Chen; Alan W. Stitt
• Keywords: RAGE; Pericyte; Leukostasis

The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. objective this study was assess the potential modulatory role RAGE diabetic retinopathy.Diabetes induced wild-type (WT) and Rage (-/-) mice (also known as Ager mice) using streptozotocin while non-diabetic control received saline. For all groups, blood glucose, HbA1c retinal levels methylglyoxal (MG) were evaluated up 24 weeks post diabetes induction. After killed, glia microglial activation, vasopermeability, leucostasis degenerative microvasculature changes determined.Retinal expression WT increased after 12 (p < 0.01) but not weeks. showed comparable accumulated less MG corresponded enhanced activity MG-detoxifying enzyme glyoxalase I their retina when compared with mice. Diabetic significantly activation 0.05-0.001). also protected against diabetes-related acellular capillary formation 0.001) pericyte loss.Rage protective many retinopathic lesions, especially those related innate immune responses. Inhibition could be therapeutic option prevent retinopathy.