Diet-dependent acid load and type 2 diabetes: pooled results from three prospective cohort studies

• DOI: 10.1007/s00125-016-4153-7
• Publication Date: 2016-11-17T12:04:13Z
• Authors: Jessica C. Kiefte...; Yanping Li; Mu Chen; Gary C. Curhan; Josiemer Mattei; Vasanti S. Malik; John P. Forman; Oscar H. Franco; Frank B. Hu
• Keywords: Adult; Male; Acid–base balance; Endocrinology, Diabetes and Metabolism; EMC OR-01; 610; Article; 03 medical and health sciences; 0302 clinical medicine; SDG 3 - Good Health and Well-being; Risk Factors; Internal Medicine; Humans; Prospective Studies; Glucose intolerance; Aged; Proportional Hazards Models; 2. Zero hunger; Acid-base balance; Insulin resistance; Middle Aged; Diet; 3. Good health; Dietary acid load; Diabetes Mellitus, Type 2; Female; Acidosis; Acids

Studies suggest a potential link between low-grade metabolic acidosis and type 2 diabetes. A western dietary pattern increases daily acid load but the association diet-dependent diabetes is still unclear. This study aimed to assess whether associated with risk of We examined energy-adjusted net endogenous production (NEAP), renal (PRAL) animal protein-to-potassium ratio (A:P) on incident in 67,433 women from Nurses' Health Study, 84,310 Study II 35,743 men Professionals' Follow-up who were free diabetes, cardiovascular disease cancer at baseline. Study-specific HRs estimated using Cox proportional hazards models time-varying covariates pooled random effects meta-analysis. documented 15,305 cases during 4,025,131 person-years follow-up. After adjustment for factors, NEAP, PRAL A:P positively (pooled HR [95% CI] highest (Q5) vs lowest quintile (Q1): 1.29 [1.22, 1.37], p trend <0.0001; 1.36], <0.0001 1.32 [1.24, 1.40], A:P, respectively). These results not fully explained by other factors including glycaemic quality (HR Q5 Q1: 1.21 [1.09, 1.33], 1.19 [1.08, 1.30] 1.26 [1.17, suggests that higher an increased overall diet quality.