Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes

• DOI: 10.1007/s00125-020-05144-1
• Publication Date: 2020-04-08T18:03:46Z
• Authors: Mari-Anne Härma; Emma H. Dahlström; Niina Sandholm; Carol Forsblom; Per-Henrik Groop; Markku Lehto
• Keywords: Adult; Male; Quality Control; Genotyping Techniques; Short Communication; Middle Aged; Kidney; Polymorphism, Single Nucleotide; 03 medical and health sciences; Cross-Sectional Studies; Diabetes Mellitus, Type 1; 0302 clinical medicine; Humans; Diabetic Nephropathies; Female; Factor XI; Plasma Kallikrein; Glomerular Filtration Rate

Abstract Aims/hypothesis Plasma kallikrein is the central mediator of plasma kallikrein–kinin system, which involved both in vascular control and thrombin formation cascades. The system has also been considered protective pathological conditions, but impact kallikreins on diabetic nephropathy remains unknown. objective this cross-sectional study was to explore association with nephropathy. Methods We measured activity 295 individuals type 1 diabetes at various stages nephropathy, we tested genetic between kidney function 4400 diabetes. Results associated duration ( p < 0.001) eGFR 0.001), lower more advanced being lowest dialysis. minor alleles KNG1 rs5030062 rs710446 variants, have previously increased pre-kallikrein and/or factor XI (FXI) protein levels, were higher (rs5030062 β = 0.03, 0.01; 0.005) FinnDiane cohort Conclusions/interpretation variants known increase level are diabetes, suggesting that might a effect