Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia

• DOI: 10.1007/s00134-009-1463-y
• Publication Date: 2009-04-02T12:57:21Z
• Authors: Guy J. Oudhuis; Judith Beuving; Dennis Bergmans; Ellen E. Stobberingh; Guul ten Velde; Catharina F. Linssen; Annelies Verbon
• Keywords: Ventilator-associated Pneumonia

Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) has proven to be a good biomarker for sepsis. For the diagnosis ventilator-associated pneumonia (VAP), however, there have only been few, relatively small, studies role of this receptor. The aim study was evaluate usefulness sTREM-1 in bronchoalveolar lavage fluid (BALF) from Intensive Care Unit patients as rapid diagnostic test VAP.The concentration 240 BALF samples measured using quantitative sandwich enzyme immunoassay. Two researchers who were blind assay results determined whether VAP present or not. Clinical suspicion confirmed by presence > = 2% cells containing intracellular organisms and/or culture result 10(4) colony forming units per millilitre BALF.The mean significantly higher with than that without VAP. However, area under receiver-operating characteristic curve 0.58 (95% confidence interval 0.50-0.65, P 0.04).The imply may not discriminative