Bone microarchitecture and bone turnover in hepatic cirrhosis

• DOI: 10.1007/s00198-019-04870-6
• Publication Date: 2019-02-20T10:10:54Z
• Authors: R. Wakolbinger; C. Muschitz; G. Scheriau; G. Bodlaj; R. Kocijan; X. Feichtinger; J. E. Schanda; J. Haschka; H. Resch; P. Pietschmann
• Keywords: Trabecular bone score; Bone remodeling

Liver cirrhosis leads to bone loss. To date, information on quality (three-dimensional microarchitecture) and, thus, strength is scarce. We observed decreased at both assessed sites, independent of disease severity. Therefore, all patients should undergo early-stage screening for osteoporosis. Recent studies found low mineral density in cirrhosis, but data microstructure are This study weight-bearing and non-weight-bearing bones with healthy controls. The primary objective was evaluate trabecular cortical microarchitecture. a single-center recently diagnosed hepatic cirrhosis. Thirty-two 32 controls participated this study. After determining the type parameters microarchitecture were by high-resolution peripheral quantitative computed tomography. Both microarchitectures showed significant alterations. At radius, volume fraction 17% lower (corrected p = 0.028), tibia, differences slightly more pronounced. Trabecular 19% (p 0.024), 7% 0.007), thickness 28% 0.001), while porosity 32% higher 0.023), compared Areal (lumbar spine − 13%, total hip 11%, body 9%, radius 17%, calcaneus 26%). There no correlation between severity (aBMD) measured dual-energy X-ray absorptiometry (DXA) correlated well Hepatic deteriorates microarchitecture, regardless diminished sites as sign generalized affection. In its origin or severity, aBMD measurements an appropriate tool osteologic screening.