Microstructural analysis of subchondral bone in knee osteoarthritis

• DOI: 10.1007/s00198-020-05461-6
• Publication Date: 2020-05-29T11:02:52Z
• Authors: L.A. Holzer; M. Kraiger; E. Talakic; G.A. Fritz; A. Avian; A. Hofmeister; A. Leithner; G. Holzer
• Keywords: Subchondral bone; Compartment (ship); Medial meniscus; Meniscus; X-ray microtomography; Lateral meniscus

The results of this study show increased formation bone in the subchondral areas advanced stages osteoarthritis knee. These changes seem to be influenced by mechanical factors.Subchondral contribute progression knee (OA). This aimed analyze microstructure specimens late-stage OA respect articular cartilage damage, meniscus integrity, and joint alignment.Thirty proximal tibiae 30 patients (20 female 10 male) with retrieved during total arthroplasty were scanned using a high-resolution micro-computed tomography. scans semi-automatically segmented into five volumes interest. interest then further analyzed commercially available software. degree damage was assessed semi-quantitatively magnetic resonance imaging before surgery.The mean fraction volume (bone volume/total (BV/TV)) all weight-bearing locations significantly higher compared non-weight-bearing reference point below anterior cruciate ligament (p = 0.000). BV/TV medial compartment lateral 0.007). As for intact menisci, there lower subluxated or luxated menisci 0.020) 0.005). Varus alignment had compartment, whereas valgus 0.011).The significant differences microstructural parameters meniscus' structural alignment. Therefore, secondary process caused changes.