Cholinesterase inhibitors, donepezil and rivastigmine, attenuate spatial memory and cognitive flexibility impairment induced by acute ethanol in the Barnes maze task in rats

• DOI: 10.1007/s00210-016-1269-8
• Publication Date: 2016-07-04T11:04:49Z
• Authors: Kinga Gawel; Krzysztof Labuz; Ewa Gibula-Bruzda; Malgorzata Jenda; Marta Marszalek-G...; Joanna Filarowska; Jerzy Silberring; Jolanta H. Kotlinska
• Keywords: Rivastigmine; Cholinesterase; Memory Impairment; Acetylcholinesterase inhibitor

Central cholinergic dysfunction contributes to acute spatial memory deficits produced by ethanol administration. Donepezil and rivastigmine elevate acetylcholine levels in the synaptic cleft through inhibition of cholinesterases—enzymes involved degradation. The aim our study was reveal whether donepezil (acetylcholinesterase inhibitor) (also butyrylcholinesterase attenuate impairment as induced administration Barnes maze task (primary latency number errors finding escape box) rats. Additionally, we compared influence these drugs on ethanol-disturbed memory. In first experiment, dose (1.75 g/kg, i.p.) selected that impaired memory, but did not induce motor impairment. Next, studied (1 3 mg/kg, i.p.), well (0.5 1 given either before probe trial or reversal learning ethanol-induced Our demonstrated drugs, when trial, were equally effective attenuating both test situations, whereas rivastigmine, at doses only a higher (3 prior learning, attenuated cognitive flexibility. Thus, appears exert more beneficial effect than reversing impairments—probably due its wider spectrum activity. conclusion, may be pharmacological manipulation central neurotransmission.