Role of curcumin on beta-amyloid protein, tau protein, and biochemical and oxidative changes in streptozotocin-induced diabetic rats

• DOI: 10.1007/s00210-024-03231-3
• Publication Date: 2024-06-26T07:02:53Z
• Authors: Mustafa Ermiş; Gülay Çiftci
• Keywords: Amyloid (mycology); Amyloid beta

Abstract Diabetes is one of the most common endocrine metabolic diseases and associated with accumulation beta-amyloid plaques in brain. Amyloid beta (Aβ) abnormal tau proteins are effective development Alzheimer’s disease. The aim this study to investigate therapeutic protective effects curcumin on protein expression levels, as well biochemical oxidative changes streptozotocin-induced diabetes rats. comprised five groups, each consisting eight rats: control, diabetic, curcumin, during diabetic induction, post-diabetic induction. Groups 2 4 were administered a single dose 45 mg/kg streptozotocin day 1, while group 5 received it 28. Curcumin was orally via gavage at 100 mg/kg/day for 35 days third, fourth, fifth groups. At end trial (day 35), blood sugar levels insulin resistance similar between control curcumin-treated groups but significantly higher ( P < 0.05). effect tested induction active diabetes. results indicated that rats displayed increased Aβ, protein, total oxidant capacity (TOS) compared Additionally, antioxidant (TAS) lower Aβ both serum brain treated > In addition, TAS following than pre-induction TOS prior However, no significant difference observed above show has an reducing stress caused by increasing activity.