Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference

• DOI: 10.1007/s00213-013-3414-0
• Publication Date: 2014-01-15T07:24:56Z
• Authors: Anja Hayen; Saira Meese-Tamuri; Amy Gates; Rutsuko Ito
• Keywords: Conditioned place preference; Basolateral amygdala; Infralimbic cortex

Increasing evidence points to the prelimbic (PL) and infralimbic (IL) cortices of medial prefrontal cortex (mPFC) their dopaminergic innervations subserving opposing roles in regulation instrumental behavior. However, it is at present unclear if they hold similar Pavlovian learning. The study investigated role PL IL modulation appetitive cue place conditioning, previously shown be dependent on basolateral amygdala hippocampus, respectively. Rats received preconditioning microinfusions d-amphetamine, cis-flupenthixol, or vehicle solution directly into were trained simultaneously acquire conditioned preference a radial maze. Preconditioning blockade dopamine neurotransmission amphetamine had same effect attenuating conditioning. In contrast, conditioning remained intact following receptor IL. Instead, was attenuated blockade. These data indicate that mechanisms are critical for acquisition learning, while may oppose influence upon hippocampal-dependent Furthermore, implicate functional reciprocity between mPFC associated subregions nucleus accumbens limbic information processing.