Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder

• DOI: 10.1007/s00213-015-4087-7
• Publication Date: 2015-09-28T23:14:35Z
• Authors: Yi-Yung Hung; Kai-Wei Huang; Hong-Yo Kang; Gloria Ya-Ling Huang; Tiao-Lai Huang
• Keywords: TLR5

Abnormalities in Toll-like receptor (TLR) expression depression have been inferred part from observed increases TLR4 levels peripheral blood mononuclear cells (PBMCs) and postmortem brains of depressed suicidal patients. Our previous study found differences the TLR PBMCs between healthy controls patients with major depressive disorder. Normalization increased by cognitive behavior psychotherapy has reported. However, effects antidepressants remain unknown.Changes TLR1-9 were examined 56 MDD. The 17-item Hamilton Depression Rating Scale (HAMD-17) mRNA TLRs assessed parallel a housekeeping gene using qRT-PCR before after treatment antidepressants.TLR3, TLR4, TLR5, TLR7, TLR8, TLR9 expressed at elevated MDD significantly decreased for 4 weeks. Antidepressant completely normalized TLR3, levels, whereas TLR1, TLR2, TLR6 to below normal levels. A subgroup analysis that only TLR3 was higher baseline nonremission group. In addition, multiple linear regression revealed low predicted improvement HAMD-17 scores.These findings suggest antidepressant exerts anti-inflammatory identify profiles as predictor response therapy. Further studies investigating manipulating individual on are needed fully elucidate underlying mechanism.