Metabolomics changes in brain-gut axis after unpredictable chronic mild stress

• DOI: 10.1007/s00213-021-05958-w
• Publication Date: 2022-02-08T07:02:51Z
• Authors: Qiuyue Xu; Mingchen Jiang; Simeng Gu; Xunle Zhang; Guangkui Feng; Xianjun Ma; Shijun Xu; Erxi Wu; Jason H Huang; Fushun Wang
• Keywords: Gut–brain axis; Chronic Stress

Major depressive disorder is a leading cause of disability worldwide, affecting up to 17 % the general population. The neural mechanisms depression, however, are yet be uncovered. Recently, attention has been drawn effects dysfunctional brain-gut axis on and many substances have suggested involved in communication between gut brain, such as ghrelin.We herein systematically examined changes metabolomics after unpredictable chronic mild stress (UCMS)-induced depression-like behaviors rats compared altered metabolites hippocampus jejunum samples.Our results show that significantly changed with UCMS both jejunum, L-glutamine, L-tyrosine, hydroxylamine, 3-phosphoglyceric acid. Further studies these reasons for anxiety-like also hippocampal plasticity.Coexistence brain metabolic UCMS-induced behavior suggests possible role depression. This study provides insights into neurobiology