Inhibitory framing in hypersexual patients with Parkinson’s disease. An fMRI pilot study

• DOI: 10.1007/s00221-022-06397-5
• Publication Date: 2022-06-28T13:03:47Z
• Authors: Hendrik Theis; Catharina Probst; Anna Campabadal; Katharina S. Goer...; Oliver Granert; Stephan Wolff; Karsten Witt; Günther Deuschl; Thilo van Eimeren
• Keywords: Hypersexuality; Sexual arousal; Stimulus (psychology)

Abstract Hypersexuality in medicated patients with PD is caused by an increased influence of motivational drive areas and a decreased inhibitory control due to dopaminergic medication. In this pilot study, we test newly developed paradigm investigating the medication on brain activation elicited sexual pictures without contextual framing. Twenty hypersexuality were examined fMRI either OFF or ON standardized The consisted priming phase where neutral context was presented. This followed target. Sexual, compared resulted BOLD various regions implicated processing. Hypersexual showed activity controls these regions. There no relevant effect between two groups. less inhibition-related hypersexual PD, but had perception cues. partially worked: reactivity cues framing lead PD. We could not find length stimulus optimal suppress Our data provide new insights into mechanisms warrant replication greater cohort optimized future.