Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana

• DOI: 10.1007/s00228-007-0369-2
• Publication Date: 2007-09-19T13:00:56Z
• Authors: Reinout Vriesendorp; Adam Cohen; Paulus Kristanto; Bernard Vrijens; Pande Rakesh; Bene Anand; Henry Uchechukwak...; Jacobus Stiekema
• Keywords: Efavirenz; Regimen; Antiretroviral medication

This pilot study was designed to evaluate the feasibility and benefits of electronic adherence monitoring antiretroviral medications in HIV patients who recently started Highly Active Anti Retroviral Therapy (HAART) Francistown, Botswana compare this with self-reporting. Dosing histories were compiled electronically using Micro Electro Mechanical Systems (MEMS) monitors prescribed therapies. Thirty enrolled treatment program monitored over 6 weeks. These all (ARV) naïve. After each visit (mean three times) pharmacy, data by downloaded. Electronic compared patient self-reports adherence. The mean individual medication level measured device 85% (range 21–100%). means self-reporting 98% 70–100%). Medication on a once-a-day dose base associated higher (97.9% for efavirenz) twice-a-day regimen (88.4% Lamivudine/Zidovudine). It is feasible assess living low resource setting HAART monitors. Adherence, even early stages treatment, appears be insufficient some may below required continuous inhibition viral replication. approach lead improved targeting counselling about their intake such order prevent occurrence resistant strains due inadequate In significant difference between recorded through those provided observed.