Characterization of Human Bladder Cell Membrane During Cancer Transformation

• DOI: 10.1007/s00232-015-9770-4
• Publication Date: 2015-01-08T14:25:53Z
• Authors: Izabela Dobrzyńska; Barbara Szachowic...; Barbara Darewicz; Zbigniew A. Figas...
• Keywords: Cell membrane; Malignant Transformation

Phenomena associated with changes in cell membranes are thought to play an important role the cancer transformation. We hypothesized that electrical charge of tumor cells can indirectly represent membrane-based have occurred during transformation and may indicate status. Here, we describe work showing phospholipids, proteins content, electric charge, all altered pT2 stage/grade G3 bladder cancer. Qualitative quantitative phospholipid composition presence integral membrane were identified using high-performance liquid chromatography. Protein was determined selective hydrolysis isolated peptide resolution. The surface density human electrophoresis. Our results show is increased levels a decreased level proteins. Moreover, process significantly enhanced membrane. In conclusion, this study demonstrates structure function modified further area warranted.