The effect of fMRI task combinations on determining the hemispheric dominance of language functions

• DOI: 10.1007/s00234-011-0959-7
• Publication Date: 2011-09-19T10:27:59Z
• Authors: Eini Niskanen; Mervi Könönen; Ville Villberg; Mikko Nissi; Perttu Ranta-aho; Laura Säisänen; Pasi Karjalainen; Marja Äikiä; Reetta Kälviäinen; Esa Mervaala; Ritva Vanninen
• Keywords: Adult; Male; Brain Mapping; Adolescent; Clinical Neurology; Functional Neuroradiology; Middle Aged; Magnetic Resonance Imaging; Functional Laterality; 03 medical and health sciences; 0302 clinical medicine; Radiology Nuclear Medicine and imaging; Image Interpretation, Computer-Assisted; Task Performance and Analysis; Humans; Female; Cardiology and Cardiovascular Medicine; Software; Language

The purpose of this study is to establish the most suitable combination functional magnetic resonance imaging (fMRI) language tasks for clinical use in determining dominance and define variability laterality index (LI) activation power between different combinations tasks. Activation patterns fMRI analyses five (word generation, responsive naming, letter task, sentence comprehension, word pair) were defined 20 healthy volunteers (16 right-handed). LIs sums T values calculated each task separately four predefined regions interest. Variability terms lateralization was analysis. In addition, visual assessment functions based on individual maps conducted by an experienced neuroradiologist. A analysis comprehension power, robustness detect essential areas, scanning time. general, provided higher overall levels than single reduced number outlier voxels disturbing calculation LI. auditory visually presented that activate aspects with sufficient may be a useful battery patients.